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Report
- Natl Cancer Inst. 1998 Oct
7;90(19):1440-50.
Multicenter
case-control study of exposure to
environmental tobacco smoke and lung
cancer in Europe.
Boffetta P, Agudo A, Ahrens W,
Benhamou E, Benhamou S, Darby SC, Ferro
G, Fortes C, Gonzalez CA, Jockel KH,
Krauss M, Kreienbrock L, Kreuzer M,
Mendes A, Merletti F, Nyberg F, Pershagen
G, Pohlabeln H, Riboli E, Schmid G,
Simonato L, Tredaniel J, Whitley E,
Wichmann HE, Saracci R, et al.
International Agency for Research on
Cancer, Lyon, France. boffetta@iarc.fr
BACKGROUND: An association between
exposure to environmental tobacco smoke
(ETS) and lung cancer risk has been
suggested. To evaluate this possible
association better, researchers need more
precise estimates of risk, the relative
contribution of different sources of ETS,
and the effect of ETS exposure on
different histologic types of lung
cancer. To address these issues, we have
conducted a case-control study of lung
cancer and exposure to ETS in 12 centers
from seven European countries. METHODS: A
total of 650 patients with lung cancer
and 1542 control subjects up to 74 years
of age were interviewed about exposure to
ETS. Neither case subjects nor control
subjects had smoked more than 400
cigarettes in their lifetime. RESULTS:
ETS exposure during childhood was not
associated with an increased risk of lung
cancer (odds ratio [OR] for ever
exposure = 0.78; 95% confidence interval
[CI] = 0.64-0.96). The OR for ever
exposure to spousal ETS was 1.16 (95% CI
= 0.93-1.44). No clear dose-response
relationship could be demonstrated for
cumulative spousal ETS exposure. The OR
for ever exposure to workplace ETS was
1.17 (95% CI = 0.94-1.45), with possible
evidence of increasing risk for
increasing duration of exposure. No
increase in risk was detected in subjects
whose exposure to spousal or workplace
ETS ended more than 15 years earlier.
Ever exposure to ETS from other sources
was not associated with lung cancer risk.
Risks from combined exposure to spousal
and workplace ETS were higher for
squamous cell carcinoma and small-cell
carcinoma than for adenocarcinoma, but
the differences were not statistically
significant. CONCLUSIONS: Our results
indicate no association between childhood
exposure to ETS and lung cancer risk. We
did find weak evidence of a dose-response
relationship between risk of lung cancer
and exposure to spousal and workplace
ETS. There was no detectable risk after
cessation of exposure.
Publication Types:
PMID: 9776409 [PubMed - indexed for
MEDLINE]
- This was
found March 2005 at the following Web
Address: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9776409&dopt=Abstract
- The above
address on PubMed will also give you an
opportunity to read the full report. The
Web address is: http://jncicancerspectrum.oupjournals.org/cgi/reprint/jnci;90/19/1440.pdf
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